Notice ID: ARPA-H-SOL-25-125
Related Notice: ARPA-H-SN-25-125
Dates (all times listed are Eastern Time):
- Proposer’s Day: January 24, 2025
- Questions & Answers (Q&A)
- Due: January 31, 2025
- Solution Summary Due Date: February 10, 2025
- Full Proposal Due Date*: estimated as no later than March 24th, 2025
- Anticipated awards: Multiple Other Transaction Agreements (OTs)
The Proactive Health Office (PHO) at ARPA-H is seeking solutions to extend the healthspan for Americans, with a focus on interventions aimed at early disease prevention. The PHO believes that population-level improvements in access to and adoption of disease prevention and wellness-promoting behaviors, novel early-detection methods, and prophylactic interventions could drastically improve Americans’ health throughout their lives, and that system-level innovations are required for effective proactive health delivery.
The PROSPR program aims to develop interventions that extend health span by 20 years by targeting the underlying causes of age-induced health loss and thereby prevent the onset of multiple age-related diseases simultaneously. To facilitate the study and testing of health span interventions, PROSPR will first reduce the time and cost investments that currently prevent a thriving health span therapeutics industry from developing. By directly demonstrating that human age-induced health outcomes can be predicted by biochemical and physiological measures in a single composite IC score, PROSPR will remove the need for 20-year clinical efficacy trials. By focusing second-generation interventions on those that target early health loss, PROSPR aims to preserve health in aging individuals before chronic diseases can develop. This will transform geriatric medicine into a personalized, comprehensive, preventive care model …
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